Osteoimmunology: Interactions of the Immune and Skeletal Systems


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This meeting is designed to bring together leading international scientists from the fields of immunology, marrow cell development and bone biology to enhance progress in understanding the relationships between these disciplines. It is now clear that immune, marrow and bone cells continually interact. Under homeostatic conditions, these interactions are critical to maintain normal physiology.

During pathologic states, the abnormal function of these cells contributes to the lesions of inflammatory arthritis, marrow failure and osteoporosis.

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The immune system. First of two parts. N Engl J Med ; Takayanagi H. Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol ; Arron JR, Choi Y. Bone versus immune system. Nature ; Leibbrandt A, Penninger JM.

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Advances in Experimental Medicine and Biology, 12 th ed. Osteoimmunology - The hidden immune regulation of bone. Autoimmun Rev ; Seeman E, Delmas PD. Bone quality - the material and structural basis of bone strength and fragility. Harada S, Rodan GA.

Osteoimmunology: interactions of the immune and skeletal systems.

Control of osteoblast function and regulation of bone mass. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation.

Cell ; Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cochran DL. Inflammation and Bone Loss in Periodontal Disease. J Periodontol ; Molecular mechanisms of inflammatory bone damage: Emerging targets for therapy. Trends Mol Med ; Gillespie MT.

Impact of cytokines and T lymphocytes upon osteoclast differentiation and function. Arthritis Res Ther ; Graves D. Cytokines that promote periodontal tissue destruction. Osteoclast differentiation and activation.

Principles of Osteoimmunology Molecular Mechanisms and Clinical Applications

Osteoimmunology: Cytokines and the skeletal system. BMB Rep ; Genetic regulation of osteoclast development and function. Nature Rev Genet ; Zinkernagel RM, Hengartner H. Regulation of the immune response by antigen. Science ; T H cells in the circle of immunity and autoimmunity. Nat Immunol ; Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med ; Autoimmune inflammation from the Th17 perspective. Treg cells suppress osteoclast formation: a new link between the immune system and bone.

Osteoimmunology: Interactions of the Immune and Skeletal Systems Osteoimmunology: Interactions of the Immune and Skeletal Systems
Osteoimmunology: Interactions of the Immune and Skeletal Systems Osteoimmunology: Interactions of the Immune and Skeletal Systems
Osteoimmunology: Interactions of the Immune and Skeletal Systems Osteoimmunology: Interactions of the Immune and Skeletal Systems
Osteoimmunology: Interactions of the Immune and Skeletal Systems Osteoimmunology: Interactions of the Immune and Skeletal Systems
Osteoimmunology: Interactions of the Immune and Skeletal Systems Osteoimmunology: Interactions of the Immune and Skeletal Systems
Osteoimmunology: Interactions of the Immune and Skeletal Systems Osteoimmunology: Interactions of the Immune and Skeletal Systems
Osteoimmunology: Interactions of the Immune and Skeletal Systems Osteoimmunology: Interactions of the Immune and Skeletal Systems
Osteoimmunology: Interactions of the Immune and Skeletal Systems Osteoimmunology: Interactions of the Immune and Skeletal Systems

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