We must design rational combinations that act upon several cellular types, including initiators of the immune response APCs and effector cells T cells. Finally, thoughtful clinical trial design is imperative to evaluate cancer vaccines at this early stage. Given the abundance of concepts coming from the laboratories, the next decade presages unprecedented growth in the development of effective cancer vaccines. The author thanks Dr.
Current status and future directions of cancer immunotherapy
Longo for his critical comments, and Ms. Kathleen Marshall for the illustrations. User Name Password Sign In. Received April 25, Accepted June 21, L earning O bjectives After completing this course, the reader will be able to: Explain the relationship between the tumor and host immune system. Recognize the mechanisms by which tumor cells escape the immune surveillance. Recognize the potential of vaccines in the treatment and prevention of cancer.
Previous Section Next Section. Figure 1. Tumor—Host Interaction Tumor cells are genetically unstable and do not have efficient mechanisms that protect against this instability [ 27 — 29 ]. View this table: In this window In a new window.
Tumor Immunology and Cancer Vaccines
Table 1. Figure 2. Table 2. Potential targets for cancer vaccines. Table 3. Cancer vaccines: strategies. Dendritic Cells Attempts to increase the efficacy of peptide vaccines have lead to the use of APCs as delivery vehicles and cellular adjuvants Fig. Figure 3. Tumor Cells Autologous and allogeneic tumor cells were one of the first types of tumor vaccines to be used [ 88 — 90 ]. Previous Section. Papac RJ. Spontaneous regression of cancer. Cancer Treat Rev ; 22 : — CrossRef Medline Google Scholar.
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The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.
Turning the corner on therapeutic cancer vaccines | npj Vaccines
Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.
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