Tumor Immunology and Cancer Vaccines: 123 (Cancer Treatment and Research)


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2.2 Dendritic cells (DCs)

We must design rational combinations that act upon several cellular types, including initiators of the immune response APCs and effector cells T cells. Finally, thoughtful clinical trial design is imperative to evaluate cancer vaccines at this early stage. Given the abundance of concepts coming from the laboratories, the next decade presages unprecedented growth in the development of effective cancer vaccines. The author thanks Dr.

Dan L.

Current status and future directions of cancer immunotherapy

Longo for his critical comments, and Ms. Kathleen Marshall for the illustrations. User Name Password Sign In. Received April 25, Accepted June 21, L earning O bjectives After completing this course, the reader will be able to: Explain the relationship between the tumor and host immune system. Recognize the mechanisms by which tumor cells escape the immune surveillance. Recognize the potential of vaccines in the treatment and prevention of cancer.

Previous Section Next Section. Figure 1. Tumor—Host Interaction Tumor cells are genetically unstable and do not have efficient mechanisms that protect against this instability [ 27 — 29 ]. View this table: In this window In a new window.

Tumor Immunology and Cancer Vaccines

Table 1. Figure 2. Table 2. Potential targets for cancer vaccines. Table 3. Cancer vaccines: strategies. Dendritic Cells Attempts to increase the efficacy of peptide vaccines have lead to the use of APCs as delivery vehicles and cellular adjuvants Fig. Figure 3. Tumor Cells Autologous and allogeneic tumor cells were one of the first types of tumor vaccines to be used [ 88 — 90 ]. Previous Section. Papac RJ. Spontaneous regression of cancer. Cancer Treat Rev ; 22 : — CrossRef Medline Google Scholar.

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  4. Emerging Opportunities and Challenges in Cancer Immunotherapy | Clinical Cancer Research.
  5. CAR T Cells: Engineering Patients’ Immune Cells to Treat Their Cancers.

Nat Med ; 4 : — Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine. J Natl Cancer Inst ; 87 : — Tumor antigens recognized by T cells. Immunol Today ; 18 : — Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.

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    Background

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    How is Immunotherapy for Lymphoma Changing the Outlook for Patients?

    Cancer Res ; 59 : — Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously. Cancer Res ; 58 : — Sznol M. Emerging concepts in cancer vaccine development. PPO Updates : 13 : 1 — A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Int J Cancer ; 73 : — From defined human tumor antigens to effective immunization? Immunol Today ; 16 : — Identification of a gene encoding a melanoma tumor antigen recognized by HLA-Arestricted tumor-infiltrating lymphocytes. J Exp Med ; : — Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes.

    The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

    Turning the corner on therapeutic cancer vaccines | npj Vaccines

    Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

    Rosenberg SA. Progress in human tumour immunology and immunotherapy. Cancer J Sci Am ; 3 : 37 — Immunization against epitopes in the human melanoma antigen gp following patient immunization with synthetic peptides. Cancer Res ; 56 : — Int J Cancer ; 87 : — An expanded peripheral T cell population to a cytotoxic T lymphocyte CTL -defined, melanocyte-specific antigen in metastatic melanoma patients impacts on generation of peptidespecific CTLs but does not overcome tumor escape from immune surveillance in metastatic lesions.

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    Tumor Immunology and Cancer Vaccines: 123 (Cancer Treatment and Research) Tumor Immunology and Cancer Vaccines: 123 (Cancer Treatment and Research)
    Tumor Immunology and Cancer Vaccines: 123 (Cancer Treatment and Research) Tumor Immunology and Cancer Vaccines: 123 (Cancer Treatment and Research)
    Tumor Immunology and Cancer Vaccines: 123 (Cancer Treatment and Research) Tumor Immunology and Cancer Vaccines: 123 (Cancer Treatment and Research)
    Tumor Immunology and Cancer Vaccines: 123 (Cancer Treatment and Research) Tumor Immunology and Cancer Vaccines: 123 (Cancer Treatment and Research)
    Tumor Immunology and Cancer Vaccines: 123 (Cancer Treatment and Research) Tumor Immunology and Cancer Vaccines: 123 (Cancer Treatment and Research)

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